Bhattacharyya Lab

Research focus

NIH R01 · 2025

Investigating the role of A20 and DREAM in adipogenesis and systemic sclerosis

PROJECT SUMMARY The pathogenesis of systemic sclerosis (SSc) is not well understood, and effective treatments are lacking. A unifying fibrosis paradigm is myofibroblast plasticity, by which quiescent resident myofibroblasts transform into activated myofibroblasts during fibrosis development. Key interactions between vascular changes and early immunological alterations occurs early in the course of disease. Loss of dermal white adipose tissue (dWAT) is another major clinical manifestation of SSc skin fibrosis. Resident mature adipocytes are lost in human and mouse skin tissues at early stage of fibrosis, yet the mechanisms that drive loss of mature adipocytes and their contribution to tissue…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.