NIH R01 · 2024
Integrative transcriptional and epigenomic modeling of xenobiotic-activated gene regulatory networks
PROJECT SUMMARY/ABSTRACT The environmental contaminant 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most potent and persistent toxicants known. TCDD and other dioxin-like chemicals are primarily ingested through food, and can cause various adverse effects ranging from immune suppression to hepatotoxicity and developmental alterations. Despite gradually decreasing environmental and body burdens, dioxin exposure remains of particular concern in utero, in breastfed infants, and specific populations reliant for food on locally caught fish and wildlife. The aryl hydrocarbon receptor (AHR), a ligand-inducible transcription factor, mediates virtually all of the toxic effects of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.