Bhattacharya Lab

Research focus

NIH R01 · 2025

Purinergic Signaling in Fibroblast Activation and Lung Fibrosis

Project Summary/Abstract Idiopathic pulmonary fibrosis (IPF) is a devastating and progressive lung disease characterized by extensive fibrotic remodeling leading to respiratory failure and death. Despite recent advancements, no curative treatments exist for IPF, underscoring the urgent need to identify novel therapeutic targets. Recent studies suggest a potential role for purinergic signaling in IPF pathogenesis, particularly through the actions of extracellular ATP (eATP): Elevated eATP levels have been observed in the bronchoalveolar lavage fluid of IPF patients, implicating this signaling molecule as a potential driver of disease progression. However, the functional impact of eATP in the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.