Bhattacharya Lab

Research focus

NIH R01 · 2025

Induction of myeloid-epithelial gap junctional channels to enhance host resilience against acute lung injury.

PROJECT SUMMARY Significance. Better understanding is required of innate mechanisms and new cell therapies that enhance host resilience against acute lung injury (ALI), and the associated acute respiratory distress syndrome (ARDS). Based on our prior findings, our premise is that gap junctional channels (GJCs) between myeloid cells and the alveolar epithelium (AE) determine host resilience to ALI. Hence, we will first, evaluate the extent to which increasing alveolar GJCs between airway-instilled bone marrow-derived monocytes (BMDMs) and the AE enhances host resilience. Second, we will evaluate the role of GJC-communicated Ca2+ waves, leading to activation of calmodulin kinase kinase-2…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.