NIH R01 · 2024
Transcriptional Regulation of Antibody Responses and Immunity
ABSTRACT The duration of antibody-mediated immunity varies widely with the specific immunization or infection for reasons that remain difficult to understand or predict. The specific features of molecular circuitry in B cells and plasma cells that are responsible for these differences have still not been defined. In this application, which requests a second renewal of our R01 award, we seek to objectively define 1) molecular programs and cellular trajectories that lead to long-lived plasma cells in primary responses; 2) transcriptional and epigenetic features of memory B cells that precede durable recall responses. We will employ two BTB-POZ transcription factors that functionally oppose…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.