NIH R01 · 2025
Targeting Angiopoietin-like 4 (ANGPTL4) in Severe Community Acquired Pneumonia
PROJECT SUMMARY Community-acquired pneumonia (CAP) is a common cause of morbidity and mortality in hospitalized patients but therapeutics are limited. In response, identification of modifiable pathways to alter host response and improve outcomes in patients with severe CAP has been highlighted as a NHLBI research priority. Our research group has identified angiopoietin-like 4 (ANGPTL4) as a potential mediator in adverse outcomes in CAP from viral and bacterial pathogens. We have generated preliminary data in a discovery proteomic analysis of 5000 different plasma proteins. We found that ANGPTL4 was one of the top proteins associated with fewer ventilator free days and worse hospital…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.