NIH R01 · 2025
Role of a gut microbiota metabolite indole lactate in myelin repair
Project Summary Multiple sclerosis (MS) is the most common neurodegenerative disease in young adults. Changes in the serum metabolome have been reported in MS and our preliminary data demonstrate that they are also associated with MS disease severity. We specifically show that aromatic amino acid-derived lactate metabolites, produced by the gut microbiota, are reduced in MS and higher levels are associated with lower disease severity. One of the metabolites indole lactate (ILA) besides being associated with lower disease severity also ameliorates neuroinflammation and promotes remyelination in animal models of MS. Our long-term goals are to demonstrate that ILA may be a novel therapeutic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.