Bhaduri Lab

University of California Los Angeles

BIOCHEMISTRY

Los Angeles · United States

NIH-funded
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NIH R01 · 2024

Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders

PROJECT SUMMARY The human brain has an expanded cortex compared to its closest relatives, and this outer layer of the brain provides humans with complex functions including integration of sensory inputs, judgement, and conscious decision making. Each of these areas of the cortex contains unique cell types, density of cells across layers, transcriptional identities, and connectivity patterns that emerge during developmental timepoints. Importantly, virtually all neurodevelopmental and neuropsychiatric disorders develop with cortical area specific phenotypes, and often with specific laminar manifestations as well. The vulnerabilities to these disorders are established during these…

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