NIH R01 · 2025
The Electrophysiological Studies of Voltage Gated Channels
Voltage sensing is found in many in biological processes and it is fundamental in excitable tissues. This project aims at understanding the physical bases of voltage sensing and how it acts on channel opening at the molecular level. We propose to find the structural basis of function with the following aims: AIM1. Understanding the voltage sensor domain (VSD)-PORE energy landscape with time-dependent temperature jumps. We have developed a method that allows for fast and homogeneous increase in temperature in the area from which function (gating and ionic currents) and the T are measured. We will explore the energy landscape of the Shaker K channel VSD-pore by applying T jumps at different…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.