NIH R01 · 2024
Critical role of Mitochondrial Fission/Fusion in Regulation of Microvascular Endothelial Function
Increased age, presence of other cardiovascular risk factors or previous treatment with anti-cancer therapy are among the leading risk factors for development of coronary artery disease (CAD). While CAD is traditionally viewed as a large vessel disease substantial recent data indicate that impaired microvascular function contributes substantially to pathophysiology and outcomes in cardiovascular disease. Subjects with a clinical diagnosis of CAD exhibit loss of NO-mediated microvascular flow-mediated dilation (FMD) concurrent with upregulation of mitochondrial hydrogen peroxide (H2O2), promoting local inflammation and cellular proliferation. Understanding the contributing mechanisms that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.