NIH R01 · 2024
Mechanotransduction in gastrointestinal physiology
PROJECT SUMMARY/ABSTRACT Disruptions in mechanosensation are commonly responsible for symptoms in diseases of gut-brain interaction (DGBI), like irritable bowel syndrome (IBS), which affect ~15% of the US population. Therefore, my laboratory’s long-term goal is to elucidate the cellular and molecular mechanisms of gastrointestinal (GI) mechanosensitivity in health and in DGBIs. There are several mechanosensory pathways in the GI tract. One such important mechanosensory pathway that is involved in DGBIs is initiated through the specialized sensory epithelial enteroendocrine cells (EECs). Upon stimulation, EECs release diverse signaling molecules that have a range of physiologic effects, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.