NIH R01 · 2025
T lymphocyte-mediated protection of the reproductive mucosa
PROJECT SUMMARY The female reproductive tract (FRT) mucosa is routinely invaded by pathogenic viruses. Resident memory CD8 T cells (TRM) have proven antiviral roles in this barrier tissue. Recent studies in mice and non-human primates have demonstrated that when present in sufficient numbers, TRM can mediate rapid antiviral protection. Responding CD8 TRM elicit immediate effector functions, recruit a network of antiviral immune cells and limit pathogen spread beyond the initial replication site. However, efforts to establish high density CD8 TRM that are durably maintained have yet to be realized. This is largely due to an incomplete understanding of the cellular and molecular signals that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.