Bettini Lab

Research focus

NIH R01 · 2024

Mechanisms of T cell persistence during chronic autoimmunity

PROJECT SUMMARY/ABSTRACT Chronic stimulation depletes memory T cell potential and leads to exhaustion. However, self-reactive autoimmune T cell responses persist and maintain function during chronic autoimmunity. The mechanisms behind persistence of autoimmune T cells, including resistance to regulatory mechanisms such as deletion and exhaustion, are not fully resolved and present a critical problem to our understanding and treatment of chronic autoimmunity. Importantly, increases in T cell exhaustion markers are correlated with autoimmune remission and positive responses to anti-CD3 therapy in type 1 diabetes (T1D), suggesting exhaustion to be an important regulatory mechanism in…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.