NIH R01 · 2025
State-dependent modulation of learning
PROJECT SUMMARY Animals can modulate learning in response to differing internal and external environments. Layering context onto learned information can enhance the diversity and specificity of memories, and can allow efficient access to situation-specific behaviors. In state-dependent learning (SDL), information learned by an animal while it is in a particular internal “state” is most effectively recalled when the animal is tested in the same internal state. Drug intoxication-induced SDL can be observed across diverse animal species, including humans. We will employ a model of ethanol intoxication-induced SDL that we have developed in the nematode Caenorhabditis elegans to define the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.