NIH R01 · 2024
Multi-cohort study of factors that influence Alzheimer's disease biomarker and dementia timing
PROJECT SUMMARY/ABSTRACT Advances in imaging and fluid-based biomarkers of Alzheimer’s disease (AD) including amyloid (A), tau (T) and neurodegeneration (N), allow detection of underlying disease pathology decades before the onset of dementia. Despite over a decade of AD biomarker research, the field still lacks the ability to accurately predict if and when individuals with preclinical AD (those with biomarker detectable pathology in the absence of cognitive symptoms) will experience dementia. Identifying factors that slow or quicken this preclinical timeframe is needed to improve dementia risk prediction for preclinical AD patients and to inform optimal treatment windows for clinical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.