NIH R01 · 2025
TNF in Injury and Repair Processes Following Traumatic SCI
Abstract Chronic neuropathic pain (CNP) is a maladaptive pathological process that is poorly understood and a condition for which no effective therapies exist. It is largely recognized that neuroinflammation significantly contributes to the development of chronic pain, however the mechanisms are not well understood. A unifying mechanism through which pathological inflammation contributes to the development of chronic pain is by being a key mediator of neuropathology and maladaptive plasticity in brain regions critical for processing somatosensory information such as the somatosensory cortex (S1). The overarching hypothesis to be tested in this competitive renewal is that strategies designed…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.