NIH R01 · 2025
Chemical glycobiology tool development: Proximity-based modalities
PROJECT SUMMARY This is a renewal application of R01GM058867 which has supported our foundational efforts in chemical glycobiology tool development since 1999. Our current goal is to leverage glycochemistry and glycobiology in the development of proximity-based technologies for use in basic research and drug development. Molecules designed to induce neo-interactions among biomolecules are now well- established research tools and emerging clinical candidates. This paradigm is embodied by proteolysis-targeting chimeras (PROTAC), bifunctional molecules that form ternary complexes with target proteins and E3 ligase enzymes, leading to their degradation by the proteasome. Targeted protein…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.