NIH R01 · 2025
An organ on-a-chip model of oral cancer and bone invasion
ABSTRACT Head and neck squamous cell carcinoma is the sixth most common cancer worldwide with approximately 600,000 new cases diagnosed each year. Oral squamous cell carcinoma (OSCC) in particular, poses a significant health challenge due to its high prevalence and aggressive nature due to its propensity to invade bone. Therefore, elucidating mechanisms of bone OSCC growth and invasion that results in bone destruction is an urgent need in craniofacial and dental research. The calcified bone matrix and cells in the bone microenvironment make up a complex puzzle of variables that have been recognized to play important roles in the progression of oral squamous cell carcinoma towards bone…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.