NIH R01 · 2025
Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII
SUMMARY Our overall goal is to understand the structural mechanisms for functional regulation of the cardiac ryanodine receptor (RyR2) and Ca/calmodulin-dependent kinase (CaMKII), two central signaling nodes causally implicated in numerous cardiac pathologies, including heart failure (HF) and arrhythmias. Our focus is on pathological states and their mitigation by drug-like compounds. Our structural studies using fluorescence resonance energy transfer in physiological environments will evolve and animate the high resolution but static cryo-EM/crystallography to the level of the dynamic heartbeat. This information is urgently needed to drive novel therapeutic strategies for arrythmia and HF.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.