NIH R01 · 2025
Project Summary There is a significant body of research into the genetic, genomic and epigenomic alterations of retinoblastoma (RB), a primary eye cancer that forms in the developing retina in young children. However, these studies were done on tumor tissues from surgically removed (enucleated) eyes with advanced RB, as tumor biopsy is not possible due to the real risk of tumor extraocular dissemination. As a result, RB tumor DNA was never previously accessible aside from these enucleated specimens, and there is limited understanding of the molecular alterations that may drive tumor behavior. Furthermore, any application of molecular diagnostic or use of prognostic biomarkers for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.