NIH R01 · 2024
Prefrontal CRF and the Regulation of Goal Directed Behavior
Project Summary The prefrontal cortex (PFC) supports a constellation of ‘executive’ cognitive processes that guide goal-directed behavior. Dysregulation of PFC-dependent cognition is associated with numerous behavioral disorders. Currently there is a strong need for improved treatments for PFC- dependent cognitive dysfunction. However, the development of novel treatments is hindered by our limited understanding of the neurobiology underlying PFC-dependent cognition. In recent studies we demonstrated that corticotropin-releasing factor (CRF) neurons in the caudal, but not rostral, dorsomedial PFC (dmPFC) of male and female rats (outside proestrus) impair two distinct cognitive processes:…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.