NIH R01 · 2024
Differentiation balances oncogene-driven proliferation to maintain epidermal homeostasis
Project Summary In skin epithelium, a population of progenitor cells distinctly capable of proliferation, self-renewal, and terminal differentiation into post-mitotic progeny, is responsible to sustain tissue homeostasis throughout life. In particular, the dynamic choice between renewal and differentiation has emerged as a critical regulator of the long-term fate of epidermal progenitors with cancer-driver oncogenic mutations, which are either rapidly eliminated through increased differentiation or tolerated as growth suppressed clones due to a stringent renewal/differentiation equilibrium. Our long-term objective is to establish how epidermal progenitor cells balance growth in the presence…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.