NIH R01 · 2025
The Genetic Epidemiology of Radiation-Associated Contralateral Breast Cancer
ABSTRACT The risk of contralateral breast cancer (CBC) after a first breast cancer diagnosis is well-documented and substantial. Radiation therapy (RT) is an important component of treatment for over half of all women with primary breast cancer yet it is a potent carcinogen and an established risk factor for future CBC. Despite major advances in defining the genetic basis of breast cancer susceptibility, and the identification of multiple risk genes with key roles in the DNA damage response (DDR), the influence of inherited genetics in modifying risk of CBC in the setting of RT, a potent carcinogen, remains poorly understood. This critical knowledge gap has hindered the ability of providers…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.