NIH R01 · 2025
DLK1 regulates HSC quiescence through phase separation mediated inhibition of receptor signaling
Project Summary: While much is known about factors that stimulate the proliferation and differentiation of stem cells, less is known about the factors that prevent their differentiation and preserve their function. One factor implicated in the maintenance of an undifferentiated stem cell state is the non-canoncial Notch ligand, Delta like homologue 1 (DLK1). DLK1 is widely expressed during embryogenesis where it regulates stem cells to control organ size. In the adult, DLK1 expression is limited to select tissues, including hematopoietic stem cells (HSC), where it has been shown to enhance the generation of primitive murine hematopoietic precursors. Yet, the precise effects of DLK1 on stem…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.