NIH R01 · 2024
Peptidoglycan Biogenesis in Escherichia Coli
SUMMARY A major goal of bacterial cell biology is to understand the mechanisms underlying the assembly and growth of the cell envelope. In addition to addressing a fundamental biological question, studies in this area have significant consequences for human health. The envelope serves as both a major target for antibiotics and, in the case of gram-negative bacteria, a formidable barrier that prevents drugs from reaching their target. Thus, understanding of the mechanisms required for construction of the gram-negative envelope will help identify new vulnerabilities in the process to target for antibiotic development. The peptidoglycan (PG) cell wall layer of the envelope is critical for cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.