NIH R01 · 2024
Modified Project Summary/Abstract Section Elevated levels of reactive oxygen species (ROS) are strongly linked to severe pathological conditions causing cardiomyopathies and neurodegeneration. Today we can utilize fluorescent probes to detect dynamic changes in ROS levels in cell physiology and pathophysiology. However, the capabilities of many ROS sensors are currently still limited by small signal amplitudes, slow kinetics, low sensitivity, in vivo incompatibility, and restraints in cellular and subcellular targeting. Thus, monitoring ROS of oxidative stress in real-time is still very restricted. Our central goal in this proposal is to resolve current limitations in ROS protein sensors.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.