NIH R01 · 2025
PROJECT SUMMARY Bioenergetic dysfunction is likely an early, critical component of neuropathogenesis of the second-most common neurodegenerative dementia, Dementia with Lewy Bodies (DLB). However, it has been difficult to elucidate the specific patterns and mechanisms of bioenergetic dysfunction, such as mitochondrial respiratory dysfunction, glycolytic failure, or failure of energy reserves in vivo in the neuropathogenesis of this disease. Elucidating the different mechanistic pathways of metabolic dysfunction involved in DLB pathogenesis, and determining the temporal sequence and pattern of these events, will be critical to developing targeted therapies. Capitalizing on our combined…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.