Berke Lab

University of California, San Francisco

NEUROLOGY

San Francisco · United States

NIH-funded
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NIH R01 · 2024

Value networks and hippocampal non-local representations

SUMMARY / ABSTRACT This proposal aims to reveal critical neural mechanisms for intelligent reward-driven learning and decision-making. It is well established that animals, including humans, use internal models of the world to guide their behavior. Model-based computations are especially vital in complex environments, where animals often need to plan a sequence of choices leading to later rewards. Furthermore, after receiving a reward animals update their reward predictions (“values”) – both for earlier choices they made, and for alternative ways of reaching that reward. These adaptive behaviors rely on combining simulations (of potential paths) with evaluations (of whether they are…

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