NIH R01 · 2025
The Role of Eosinophils in Modulating the Corneal Response to Infection
Project Summary/Abstract Objective/Hypothesis: Pseudomonas aeruginosa is an opportunistic bacterium known to induce microbial keratitis and is associated with rapid corneal destruction and blindness, especially in individuals who wear contact lenses or are immunocompromised. Microbial keratitis triggers a robust inflammatory response driven by the influx of innate immune cells. During infection, neutrophils (PMNs) and macrophages (Mϕ) are recruited in the acute phase of inflammation to effectively remove the pathogen. However, their persistence and chronicity can lead to extensive tissue destruction, including corneal opacity, stromal fibrosis, and ulceration, if not properly treated.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.