NIH R01 · 2025
Early Detection of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related death in the United States. To address the magnitude of this problem, it is critically important to identify those at high risk for HCC and institute effective surveillance strategies for early diagnosis. Liver cirrhosis is the main risk factor for HCC. Bi- annual ultrasound and α-fetoprotein remains the surveillance modality most frequently used in patients with cirrhosis, despite very low sensitivity and specificity. Our goals are to identify a blood-based model for risk stratification in patients with cirrhosis, as well as an integrated blood-based and liver imaging model to optimize early HCC detection in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.