NIH R01 · 2025
Lymphatic drainage dysfunction in chronic hypertension
Abstract Malfunction of the brain’s waste clearing glymphatic system has been shown to play a key role in cerebral small vessel disease the most common cause of vascular cognitive impairment prevalent with chronic hypertension in the aging population. Cerebral small vessel disease (cSVD) affects 750 million people worldwide, causes up to 45% of all dementias, and accounts for ~20% of all stroke cases, yet the underlying pathophysiology - even in the setting of hypertension - remains incompletely understood. Remarkably, the status of the lymphatic system (LS) has not been investigated in cSVD. We have novel data showing functional impairment of the LS a cSVD rat model with chronic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.