NIH R01 · 2025
CYP4F Enzymes Regulate N-Acyl Amino Acid Signaling in Humans
PROJECT SUMMARY Obesity and obesity-related type 2 diabetes (T2D) pose major health threats in the US, however the early pathophysiology of these diseases remain incompletely defined. Blood-borne lipid signaling molecules called lipokines are an emerging class of endocrine factors that control systemic energy and glucose homeostasis and offer significant potential as therapeutic targets in human metabolic disease. We recently discovered that an unusual family of lipokines that consist of fatty acid-amino acid conjugates called N-acyl amino acids stimulate energy expenditure and thereby reduce body weight and improve glucose tolerance in murine models of obesity. To define the role of N-acyl…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.