Bensinger Lab

Research focus

NIH R01 · 2024

Investigating the impact of a fatty acid-cRel inflammatory circuit in atherosclerosis

R01: Investigating the impact of a fatty acid–cRel inflammatory circuit in atherosclerosis ABSTRACT/SUMMARY The objective of this grant to is to understand how inflammation and lipid metabolism are linked via circuits within macrophages, and whether these circuits influence cardiometabolic disease. Although perturbations in lipid homeostasis are recognized to be associated with inflammation in a number of human diseases, our understanding of “how” and “why” the processes are intimately linked remains limited. Recent work has revealed that pro-inflammatory signals can reprogram the lipid metabolic state of macrophages. It has also become clear that perturbations in lipid homeostasis can be…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.