NIH R01 · 2025
EpiGNOME: Epigenetic Graphical Networks Of Methylation Effectors for COPD Progression
EpiGNOME: Epigenetic Graphical Networks Of Methylation Effectors for COPD Progression ABSTRACT Modern clinical and translational sciences rely on big data to identify drivers of disease progression and develop predictors of disease outcomes. Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death and likely represents several molecular subtypes, which makes the prognosis and treatment challenging. Genetic variation only explains a fraction of COPD pathogenesis. DNA methylation variability is particularly important since it is more stable than gene expression and captures genetic influences and longitudinal exposures. Despite its likely prominent role in disease and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.