NIH R01 · 2025
Orchestrating Tendon Regeneration through Nanoparticle Drug Delivery
Project Summary Tendon regeneration following acute injury is marred by a fibrotic healing response that impairs complete functional recovery. Despite the frequency of injuries and complications associated with poor healing, including re-injury and limited range of motion, no pharmacological approaches exist to improve tendon healing. While several interventions have been proposed, systemic treatments lack tendon specificity, resulting in poor tendon biodistribution and off-target toxicities. We recently made the serendipitous discovery via spatial transcriptomic profiling that inflammatory tissue at the healing tendon site is enriched for expression of Acp5, the gene encoding…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.