Bennett Lab

University of Colorado Denver

PEDIATRICS

Aurora · United States

NIH-funded
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NIH R01 · 2025

Novel Pediatric Sepsis Criteria and Clinical Decision Support Tools

PROJECT SUMMARY/ABSTRACT Pediatric sepsis is a major global public health problem associated with millions of deaths every year. In the United States, 1 in every 10-15 children with sepsis or septic shock will die during their hospitalization, and many survivors will have a lower health-related quality of life. We collaborated with an international task force to develop and validate the novel Phoenix criteria for sepsis and septic shock in children, which were published in two high-impact articles in JAMA and are now the reference standard for diagnosing pediatric sepsis around the world.8,9 The criteria are based on the Phoenix Sepsis Score (PSS), which we developed using a data- driven…

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