NIH R01 · 2024
Dynamics and pattern formation in differentiating cellular populations
PROJECT SUMMARY (See instructions): One hallmark of complex multicellular life is the ability of stem cells to asymmetrically differentiate into multiple cell types - i.e. the ability for a stem cell to give birth to a new cell type while retaining its own. The regulation of asymmetric cell division is important for organismal development and processes such as tissue regeneration and homeostasis. Its improper regulation can lead to aberrant cell growth, abnormal development (malformation, dysplasia), and tumor formation. From a mathematical modeling perspective, asymmetric cell division and its regulation are difficult to study because naturally occurring systems are complex and often only…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.