NIH R01 · 2025
Project Summary A role for B-cells in multiple sclerosis (MS) pathogenesis has been implicated by clinical, histopathologic and immunologic studies. The precise role they play in pathology is debated and impact could be mediated through antibody (Ab) production, secretion of pro-inflammatory cytokines, or antigen presentation to T cells. To study Abs produced by MS CSF B cell clones, we developed protocols to produce recombinant antibodies that duplicate the fidelity of CD138+ plasmablast clones expanded in the CSF compartment of early active MS patients. We identified a subset of antibodies that bound to myelin and induced complement-mediated oligodendrocyte cell death and demyelination in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.