NIH R01 · 2024
Risk Factors, Pathology, and Clinical Expressions of AD
ABSTRACT Over the past project periods we tracked the biological basis of cognitive decline and dementia to understand the heterogeneous contributions of a dozen brain pathologies to individuals in the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). We identified numerous genomic, medical, experiential, and psychological factors associated with cognitive decline and incident Alzheimer’s dementia, and also neurobiologic pathways linking some of these factors to Alzheimer’s disease (AD) and to related dementias. In the most recent funding period, to understand the biological basis of risk factors, we analyzed multi-region multi-omic data to identify novel and potentially…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.