NIH R01 · 2024
Mechanisms of oxysterol-induced oligodendrogenesis
Abstract: White matter injury is the most common neonatal brain injury leading to poor neurologic outcomes in premature infants. This injury results in both focal and/or diffuse losses of oligodendrocytes, the myelinating cells in the brain. Hypoxia and inflammation are common and important risk factors within this vulnerable population and there are no treatment options available. A significant challenge to the development of novel treatment strategies for brain injury in neonates is the appropriate concern for safety. To de-risk innovative therapeutic development in this field, we focused on the identification of endogenous signaling molecules present in human maternal breast milk to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.