NIH R01 · 2025
CARMIL1 and Endothelial Barrier Function Regulation
ABSTRACT The acute respiratory distress syndrome (ARDS) is characterized by pulmonary vascular leak and flooding of the normally air-filled alveolar space with protein rich edema fluid and causes severe hypoxemia, respiratory failure and death among critically ill patients. Identification of genetic factors which modify the risk of developing ARDS or influence clinical outcomes may improve our pathologic understanding of this disease. Human variants in the gene LRRC16A are implicated in improved ARDS outcomes but the mechanism remains unknown. LRRC16A encodes capping protein, Arp 2/3 and myosin-I linker (CARMIL1), a cytoskeletal regulatory protein which has been studied primarily in cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.