NIH R01 · 2024
Improving sarcopenia by targeting mitochondria
Sarcopenia, the age-related loss of skeletal muscle mass and function, predicts for morbidity, mortality and excessive healthcare costs. Other than exercise, lifestyle therapies for slowing the progression of sarcopenia in older men and women remain elusive. Mitochondrial dysfunction is a common mechanistic link between aging and many pathological factors contributing to sarcopenia. We propose to test whether supplementing the diet with an oil rich linoleic acid (LA; 18:2n6), the preferred fatty acyl constituent of cardiolipin, improves muscle strength and physical mobility. In mice, dietary LA-rich oil increases LA-rich cardiolipin (e.g., 4-LA- cardiolipin) and mitochondrial respiration.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.