NIH R01 · 2024
Infection-specific lipid metabolism as a target to control enterovirus infections
Project Summary Infection-specific lipid metabolism as a target to control enterovirus infections The development of the membranous replication organelles is a crucial step in the life cycle of all positive-strand RNA viruses of eukaryotes, including enteroviruses. The unique lipid and protein composition of the replication organelles is essential for the functioning of the viral enzymatic replication machinery, and the membranes likely hide the replication complexes containing dsRNA from the sensors and effectors of the cellular anti-viral response. In the case of enteroviruses, the structural and functional development of the replication organelles requires a profound reconfiguration of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.