NIH R01 · 2024
Chromatin Domain Structure and Function
Transcriptional regulation is fundamental to most basic molecular and cell biological processes. Our long-term goals are to determine how 10 and 30 nm chromatin fibers fold into large-scale chromatin domains, how these chromatin domains are moved and positioned within nuclei relative to specific nuclear bodies and compartments, and what this means for DNA functions such as transcription and replication. Our first Aim is to dissect both transcription independent and transcription dependent mechanisms for genome positioning relative to nuclear speckles. Our rationale is that gene positioning relative to nuclear speckles modulates levels of gene expression possibly for thousands of genes, and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.