NIH R01 · 2025
Project Summary/Abstract. Stress and a parental history of Major Depressive Disorder (MDD) are among the most potent risk factors for future MDD development. Evidence suggests that the offspring of parents with MDD are especially vulnerable to the development of maladaptive responses to stress. Early adolescence is a critical window for studying MDD risk, as this developmental stage is just prior to the peak period of initial MDD onsets and a time of enhanced stress sensitivity, especially among females. Despite the importance of stress in MDD onset, the neural mechanisms underlying stress responses in female adolescents at high familial risk for MDD remain unclear. Furthermore, little is…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.