NIH R01 · 2024
Novel mechanisms of HIV-associated pulmonary vascular disease
PROJECT SUMMARY Thanks to the advent of combination antiretroviral therapy (cART), life expectancy has dramatically increased in people with HIV (PWH) and the spectrum of diseases related to HIV has shifted towards non-infectious chronic illnesses including cardiopulmonary disorders. Pulmonary vascular disease (PVD) is amongst the most devastating cardiovascular complications of HIV. However, the etiopathology of pulmonary vascular remodeling, the critical structural alteration and pathological feature for PVD, has yet to be determined. Herein, we will test whether HIV-derived proteins, which remain in circulation despite cART and well-controlled viremia, contribute to the development of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.