NIH R01 · 2024
Role Of Retinoid Oxidoreductase Complex In Controlling The Embryonic Development
ABSTRACT All-trans-retinoic acid (RA) is the main physiologically active derivative of vitamin A, which serves as a ligand for nuclear transcription factors, RA receptors. During development, RA is produced in a quickly changing spatiotemporal pattern to control the expression of precise sets of genes at different developmental stages. Critical RA-sensitive processes during development are RA-concentration dependent, which underscores the importance of the precise control over RA synthesis in a strictly defined and rapidly regulated manner. Biosynthesis of RA includes reversible rate-limiting oxidation of retinol to all-trans-retinaldehyde, followed by irreversible oxidation of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.