NIH R01 · 2025
Novel applications and translation of [18F]hGTS13, a system xc- specific radiopharmaceutical
ABSTRACT. Ferroptosis is a form of regulated cell death defined by the iron-dependent accumulation of membrane lipid peroxides that results in oxidative damage and plasma membrane disruption. Ferroptosis is a form of cell death that is mechanistically and morphologically distinct from other forms of cell death, such as necroptosis, apoptosis, and pyroptosis. Targeting ferroptosis has garnered immense interest in the cancer research community owing to the potential to selectively active this mechanism of cell death in cancer cells. To realize the full potential of inducing ferroptosis in cancer, non-invasive imaging markers are needed. System xc-, the cystine-glutamate antiporter, is a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.