NIH R01 · 2024
Vinyl chloride modifies the risk for nonalcoholic fatty liver disease
NAFLD is a major health problem in the developed world that is driven by the epidemic of obesity and metabolic syndrome. Although the prevalence of early stage NAFLD (fatty liver) is nearly 100% in at-risk individuals, the more severe form of the disease (NASH>fibrosis>cirrhosis>HCC) is much lower, indicating that other factors drive interindividual risk for severe NAFLD. We hypothesize that vinyl chloride (VC) is such a factor. We have shown that VC inhalation at concentrations relevant to human environmental exposure exacerbates experimental NAFLD in mice by causing oxidative stress and mitochondrial dysfunction. Mitochondrial quality and abundance, regulated by autophagy, affect the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.