NIH R01 · 2024
Reproductive tract organ development and differentiation
Project Summary Mammalian embryos have the potential to develop both male and female reproductive tract organs. However, they typically only differentiate one sex type depending on the presence or absence of fetal gonadal hormones. Two paired epithelial ducts form within the mesonephroi (fetal kidneys) in both genetically male and female embryos. The Wolffian ducts form first and with the adjacent mesenchyme differentiate into male organs, including the vasa deferens, epididymis, and seminal vesicle. The Müllerian ducts then form adjacent to the Wolffian ducts. The Müllerian ducts and their adjacent mesenchyme give rise to female organs, including oviduct, uterus, vagina. In male embryos,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.